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The zebrafish as an emerging model to study DNA damage in aging, cancer and other diseases

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Nature 496 , 518522 (2013)

By elucidating the mechanisms by which our internal timekeepers influence fundamental metabolic processes, we can unlock new opportunities for the development of more effective, personalised, and circadian-aligned approaches to the prevention and management of metabolic disorders

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The system is reset by phosphorylation, ubiquitination and proteasomal degradation of the Per/Cry repressor complexes (163,164)